The ASIC (Acid Sensing Ion Channel) Targeted Venom Discovery Array™ (T-VDAASIC) is specifically designed to maximise discovery of new tools. ASIC channels are important drug targets for neurological disorders, specifically pain. ASIC channel tools from theraphosids (tarantulas) and snakes are the most potent and selective agents currently known. These targeted arrays contain pure venom fractions from 12, 24, 48 or 96 species optimised for identification of novel tools. Each array contains characterised venoms active at ASIC channels from the literature to act as positive controls. The control venoms for T-VDAASIC include Psalmopoeus cambridgei (Trinidad chevron tarantula) which contains Psalmotoxin, a selective blocker of ASIC1a channels [1]; Dendroaspis polylepis (Black mamba) venom which contains Mambalgins that block ASIC1a/2a heteromers [2]; and Dendroaspis angusticeps (Eastern green mamba) venom which contains mambalgin-3 that blocks ASIC1a and ASIC1b channels as well as 1a/2b heteromers [3]. Other venom fractions making up the library have been specially selected by our drug discovery scientists to maximise novel hit potential.

• Venoms are supplied lyophilised in Echo qualified acoustic source plates (Labcyte Inc) and are useable on any SBS footprint liquid handling device or by hand.

• 384-well format has 200ng venom fraction per well, suggested dilution 20µl as hit fractions are typically active at 5µg/ml and below.

• 1536-well format also available.